Konstantinidou Group
Group members
SNF Prof. Dr. Georgia Konstantinidou, PhD
Group members
- Name / Titel
- Chiara Pozzato
- Funktion
- PhD student
- chiara.pozzato@pki.unibe.ch
- Phone
- +41 31 6320220
- Name / Titel
- Flavia Fico
- Funktion
- Postdoc
- flavia.fico@pki.unibe.ch
- Name / Titel
- Maria Saliakoura
- Funktion
- Postdoc
- maria.saliakoura@pki.unibe.ch
- Phone
- +41 31 6320220
- Name / Titel
- Cedric Leroux
- Funktion
- PhD student
- cedric.leroux@pki.unibe.ch
- Phone
- +41 31 632 02 20
- Name / Titel
- Thomas Bertotto
- Funktion
- PhD student
- thomas.bertotto@pki.unibe.ch
- Name / Titel
- Simone Falco
- Funktion
- PhD student
- simone.falco@pki.unibe.ch
- Name / Titel
- Raphael Aregger
- Funktion
- Master student
former Group members
Dr. Asmita Thapa postdoc (2021)
Thierry Paschoud MSc (2021)
Dr. Matteo Rossi Sebastiano PhD (2020); postdoc (2020)
CV Dr. G. Konstantinidou
ACADEMIC APPOINTMENTS (The places of mobility are in bold)
January 2006-March 2009 PhD Degree in Molecular and Cancer Biology
University of Camerino, Italy
(Mentor: Augusto Amici)
May 2009-December 2012 Postdoctoral Fellow
University of Texas Southwestern Medical Center, Dallas, USA
(Mentor: Pier Paolo Scaglioni)
January 2013-July 2016 Postdoctoral Fellow
University of Geneva, Switzerland
(Mentor: Robbie Joseph Loewith)
August 2016-Present Swiss National Science Foundation (SNSF) Professor
University of Bern, Switzerland
EDUCATION
September 2000-December 2005 Biological Sciences Degree (Magna cum Laude)
University of Camerino, Italy
January 2006-March 2009 PhD Degree in Molecular and Cancer Biology
University of Camerino, Italy
(Mentor: Augusto Amici)
May 2009-December 2012 Postdoctoral Fellow
University of Texas Southwestern Medical Center, Dallas, USA
(Mentor: Pier Paolo Scaglioni)
January 2013- July 2016 Postdoctoral Fellow
University of Geneva, Switzerland
(Mentor: Robbie Joseph Loewith)
TRAINING AND RESEARCH
January 2006-March 2009: PhD in Biology, University of Camerino, Camerino, Italy. Research Advisor: Amici Augusto.
2007 (February-March): Internship, Molecular Biotechnology Center, University of Turin. Research advisor: Defilippi Paola.
2007 (September-October): Internship, Molecular Biotechnology Center, University of Turin. Research advisor: Defilippi Paola.
November 2007-March 2009: Exchange visitor student program at UT Southwestern Medical Center, Dallas, Texas. Research advisor: Pier Paolo Scaglioni.
May 2009-December 2012: Postdoctoral fellow at UT Southwestern Medical Center, Dallas, Texas. Research advisor: Pier Paolo Scaglioni.
January 2013 - July 2016: Postdoctoral fellow at University of Geneva, Switzerland. Research advisor: Robbie Joseph Loewith.
August 2016-Present: Swiss National Science Foundation (SNSF) Professor, University of Bern, Switzerland
Projects
Publications
BORIS
2021
Leroux, Cédric; Konstantinidou, Georgia (2021). Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology. Cancers, 13(4) MDPI AG 10.3390/cancers13040799
2020
Saliakoura, Maria; Rossi, Sebastiano Matteo; Pozzato, Chiara; Heidel, Florian H.; Schnöder, Tina M.; Savic Prince, Spasenija; Bubendorf, Lukas; Pinton, Paolo; Schmid, Ralph A.; Baumgartner, Johanna; Freigang, Stefan; Berezowska, Sabina A.; Rimessi, Alessandro; Konstantinidou, Georgia (2020). PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Nature cell biology, 22(11), pp. 1382-1395. Springer Nature 10.1038/s41556-020-00592-8
Rossi Sebastiano, Matteo; Pozzato, Chiara; Saliakoura, Maria; Zhang, Yang; Peng, Ren-Wang; Galiè, Mirco; Oberson, Kevin; Simon, Hans-Uwe; Karamitopoulou, Evanthia; Konstantinidou, Georgia (2020). ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression. Science Advances, 6(44), pp. 1-15. American Association for the Advancement of Science 10.1126/sciadv.abb9200
Saliakoura, Maria; Reynoso-Moreno, Inés; Pozzato, Chiara; Rossi Sebastiano, Matteo; Galié, Mirco; Gertsch, Jürg; Konstantinidou, Georgia (2020). The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer. Oncogene, 39(14), pp. 2948-2960. Springer Nature 10.1038/s41388-020-1196-5
Ramadori, Giorgio; Ioris, Rafael M; Villanyi, Zoltan; Firnkes, Raquel; Panasenko, Olesya O; Allen, George; Konstantinidou, Georgia; Aras, Ebru; Brenachot, Xavier; Biscotti, Tommasina; Charollais, Anne; Luchetti, Michele; Bezrukov, Fedor; Santinelli, Alfredo; Samad, Muntaha; Baldi, Pierre; Collart, Martine A; Coppari, Roberto (2020). FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth. Cell reports, 30(11), pp. 3851-863. Cell Press 10.1016/j.celrep.2020.02.082
Konstantinidou, Georgia; Rimessi, Alessandro (2020). Editorial: Oncogenic RAS-Dependent Reprogramming of Cellular Plasticity. Frontiers in oncology, 10(588), p. 588. Frontiers Research Foundation 10.3389/fonc.2020.00588
2019
Rossi Sebastiano, Matteo; Konstantinidou, Georgia (2019). Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy. International journal of molecular sciences, 20(15) Molecular Diversity Preservation International MDPI 10.3390/ijms20153624
2017
Ioris, Rafael M.; Galié, Mirco; Ramadori, Giorgio; Anderson, Jason G.; Charollais, Anne; Konstantinidou, Georgia; Brenachot, Xavier; Aras, Ebru; Goga, Algera; Ceglia, Nicholas; Sebastián, Carlos; Martinvalet, Denis; Mostoslavsky, Raul; Baldi, Pierre; Coppari, Roberto (2017). SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity. Cell reports, 18(8), pp. 1858-1868. Cell Press 10.1016/j.celrep.2017.01.065
2016
Padanad, Mahesh S; Konstantinidou, Georgia; Venkateswaran, Niranjan; Melegari, Margherita; Rindhe, Smita; Mitsche, Matthew; Yang, Chendong; Batten, Kimberly; Huffman, Kenneth E; Liu, Jingwen; Tang, Ximing; Rodriguez-Canales, Jaime; Kalhor, Neda; Shay, Jerry W; Minna, John D; McDonald, Jeffrey; Wistuba, Ignacio I; DeBerardinis, Ralph J; Scaglioni, Pier Paolo (2016). Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell reports, 16(6), pp. 1614-1628. Cell Press 10.1016/j.celrep.2016.07.009
2015
Ramadori, Giorgio; Konstantinidou, Georgia; Venkateswaran, Niranjan; Biscotti, Tommasina; Morlock, Lorraine; Galié, Mirco; Williams, Noelle S.; Luchetti, Michele; Santinelli, Alfredo; Scaglioni, Pier Paolo; Coppari, Roberto (2015). Diet-Induced Unresolved ER Stress Hinders KRAS-Driven Lung Tumorigenesis. Cell metabolism, 21(1), pp. 117-125. Cell Press 10.1016/j.cmet.2014.11.020
Gaubitz, Christl; Oliveira, Taiana M.; Prouteau, Manoel; Leitner, Alexander; Karuppasamy, Manikandan; Konstantinidou, Georgia; Rispal, Delphine; Eltschinger, Sandra; Robinson, Graham C.; Thore, Stéphane; Aebersold, Ruedi; Schaffitzel, Christiane; Loewith, Robbie (2015). Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Molecular cell, 58(6), pp. 977-988. Cell Press 10.1016/j.molcel.2015.04.031
2013
Konstantinidou, Georgia; Ramadori, Giorgio; Torti, Francesca; Kangasniemi, Kim; Ramirez, Rachel E.; Cai, Yiran; Behrens, Carmen; Dellinger, Michael T.; Brekken, Rolf A.; Wistuba, Ignacio I.; Heguy, Adriana; Teruya-Feldstein, Julie; Scaglioni, Pier Paolo (2013). RHOA-FAK Is a Required Signaling Axis for the Maintenance of KRAS-Driven Lung Adenocarcinomas. Cancer discovery, 3(4), pp. 444-457. American Association for Cancer Research 10.1158/2159-8290.CD-12-0388
2012
Rabellino, A.; Carter, B.; Konstantinidou, Georgia; Wu, S.-Y.; Rimessi, A.; Byers, L. A.; Heymach, J. V.; Girard, L.; Chiang, C.-M.; Teruya-Feldstein, J.; Scaglioni, P. P. (2012). The SUMO E3-ligase PIAS1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA. Cancer research, 72(9), pp. 2275-2284. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-11-3159
Scaglioni, Pier Paolo; Rabellino, Andrea; Yung, Thomas M.; Bernardi, Rosa; Choi, Sooyeon; Konstantinidou, Georgia; Nardella, Caterina; Cheng, Ke; Pandolfi, Pier Paolo (2012). Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence. EMBO molecular medicine, 4(7), pp. 594-602. EMBO Press 10.1002/emmm.201200233
Bisaro, Brigitte; Montani, Maura; Konstantinidou, Georgia; Marchini, Cristina; Pietrella, Lucia; Iezzi, Manuela; Galiè, Mirco; Orso, Francesca; Camporeale, Annalisa; Colombo, Shana M; Di Stefano, Paola; Tornillo, Giusy; Camacho-Leal, Maria P; Turco, Emilia; Taverna, Daniela; Cabodi, Sara; Amici, Augusto; Defilippi, Paola (2012). p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast cancer research, 14(5), R137. BioMed Central Ltd. 10.1186/bcr3342
2010
Marchini, Cristina; Montani, Maura; Konstantinidou, Georgia; Orrù, Rita; Mannucci, Silvia; Ramadori, Giorgio; Gabrielli, Federico; Baruzzi, Anna; Berton, Giorgio; Merigo, Flavia; Fin, Stefania; Iezzi, Manuela; Bisaro, Brigitte; Sbarbati, Andrea; Zerani, Massimo; Galiè, Mirco; Amici, Augusto; Shioda, Toshi (2010). Mesenchymal/Stromal Gene Expression Signature Relates to Basal-Like Breast Cancers, Identifies Bone Metastasis and Predicts Resistance to Therapies. PLoS ONE, 5(11), e14131. Public Library of Science 10.1371/journal.pone.0014131
2009
Konstantinidou, Georgia; Bey, E. A.; Rabellino, A.; Schuster, K.; Maira, M. S.; Gazdar, A. F.; Amici, A.; Boothman, D. A.; Scaglioni, P. P. (2009). Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non-Small Cell Lung Cancer Harboring K-RAS Mutations. Cancer research, 69(19), pp. 7644-7652. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-09-0823
2008
Scaglioni, P. P.; Yung, T. M.; Choi, S. C.; Baldini, C.; Konstantinidou, Georgia; Pandolfi, P. P. (2008). CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor. Molecular and cellular biochemistry, 316(1-2), pp. 149-154. Springer 10.1007/s11010-008-9812-7
Galiè, M; Konstantinidou, Georgia; Peroni, D; Scambi, I; Marchini, C; Lisi, V; Krampera, M; Magnani, P; Merigo, F; Montani, M; Boschi, F; Marzola, P; Orrù, R; Farace, P; Sbarbati, A; Amici, A (2008). Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice. Oncogene, 27(18), pp. 2542-2551. Nature Publishing Group 10.1038/sj.onc.1210920
Selected Publications:
Ioris R.M., Galié M.1, Ramadori G., Anderson J.G., Charollais A., Konstantinidou G., Brenachot X., Aras E., Goga A., Ceglia N., Sebastián C., Martinvalet D., Mostoslavsky R., Baldi P., Coppari R. SIRT6 suppresses cancer stem-like capacity in tumors with PI3K activation independently of its deacetylase activity. Cell Reports 2017 DOI: 10.1016/j.celrep.2017.01.065
Mahesh S. Padanad#, Georgia Konstantinidou#, Niranjan Venkateswaran, Margherita Melegari, Smita Rindhe, Matthew Mitsche, Chendong Yang, Kimberly Batten, Kenneth E. Huffman, Jingwen Liu, Ximing Tang, Jaime Rodriguez-Canales, Neda Kalhor, Jerry W. Shay, John D. Minna, Jeffrey McDonald, Ignacio I. Wistuba, Ralph J. DeBerardinis, and Pier Paolo Scaglioni. Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell Reports 2016 DOI: 10.1016/j.celrep.2016.07.009
# Equal contribution.
Christl Gaubitz, Taiana M. Oliveira, Manoel Prouteau, Alexander Leitner, Manikandan Karuppasamy, Georgia Konstantinidou, Delphine Rispal, Sandra Eltschinger, Graham C. Robinson, Stéphane Thore, Ruedi Aebersold, Robbie Loewith, and Christiane Schaffitzel. Structural basis of the rapamycin insensitivity of Target Of Rapamycin Complex 2. Mol. Cell 2015 DOI: 10.1016/j.molcel.2015.04.031
Giorgio Ramadori#, Georgia Konstantinidou#, Niranjan Venkateswaran, Tommasina Biscotti, Lorraine Morlock, Mirco Galie´, Noelle S. Williams, Michele Luchetti, Alfredo Santinelli, Pier Paolo Scaglioni and Roberto Coppari. Diet-induced Unresolved ER stress Hinders KRAS-Driven Lung Tumorigenesis. Cell Metab. 2014 DOI: 10.1016/j.cmet.2014.11.020
# Equal contribution.
Konstantinidou G, Ramadori G, Torti F, Kangasniemi K, Ramirez RE, Cai Y, Behrens C, Dellinger MT, Brekken RA, Wistuba II, Heguy A, Teruya-Feldstein J, Scaglioni PP. RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas. Cancer Discov. 2013 DOI: 10.1158/2159-8290.CD-12-0388
Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, Pier Paolo Scaglioni. Dual PI3K/mTOR blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS Mutations. Cancer Res 2009. DOI: 10.1158/0008-5472.CAN-09-0823